Have you ever observed that while eating one serving of a particular food may make you feel happy and content, eating three portions may make you feel uneasy or anxious? If yes, you are currently experiencing cannabis' biphasic effects.
Different cannabinoid concentrations, like CBD and THC, produce a range of physical and mental effects through the biphasic effects of cannabis. One cannabinoid may cause a person to feel alert at high doses while making them feel relaxed at lower doses.
What Does “Biphasic Effect” Mean?
A medication has a biphasic impact when its effects are opposing at both low and high dosages. For instance, some people find that little amounts of THC help them relax. However, taking large amounts of THC may give those same folks a paranoid feeling and, in some situations, may even cause hallucinations.
However, biphasic effects are not exclusive to cannabis; other medicines have the same effects at high and low doses. For instance, alcohol may give you a pleasurable "high" in moderate doses, but in large doses, it can have a depressive effect that makes you melancholy.
The hippocampus in particular, the brain's processing of chemicals, is the basis for all biphasic effects. Dopamine receptors, serotonin receptors, and other important neurotransmitters all respond differently to various cannabis and other drug dosages.
The Biphasic Effects of Cannabis
Compared to CBD and other lesser cannabinoids, THC's biphasic effects call for more caution. This is due to the fact that THC has the greatest effect on people's feelings, perceptions, and physical responses. Here are a few instances of THC's probable biphasic effects supported by science:
Memory and cognition: Positive effect on memory and cognition in low doses, negative effect in high doses
Anxiety: Decreases anxiety in low doses and increases anxiety in high doses
Fertility: More fertility in low doses, less fertility in high doses
In terms of fertility, lesser doses are more fertile whereas high doses are less fertile.
Instead of using human subjects, many studies on the biphasic effects of THC use animal models. To comprehend the potential biphasic effects of THC, more human clinical trials and research are required.
Although to a lesser extent than its psychoactive sibling, THC, CBD is likewise biphasic. In general, CBD has calming effects in greater dosages and more stimulating effects in lower levels. These biphasic effects might be more pronounced with THC and CBD in people who have been diagnosed with anxiety or panic disorder.
Tetrahydrocannabivarin is another cannabinoid with characteristic biphasic effects (THCV). In low doses, THCV is anti-psychoactive, which means it can lessen some of the psychoactivity of THC, and in higher doses, it is psychoactive, which means it can synergize with THC and slightly increase cannabis' psychoactivity.
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